摘要：目的 基于文献对中医治疗尿道结石用药规律的进行研究。方法 检索中国期刊全文数据库(CNKI)1985－2012年涉及尿道结石中医处方用药的临床研究文献,建立数据库,采用SPSS12.0统计软件进行统计分析。结果 纳入符合要求的中医药治疗尿道结石文献209篇,涉及内服复方209首,中药234种,总用药次数为1843次。所用中药种类以利水渗湿药、补虚药、活血化瘀药、理气药、清热药、消食药、泻下药为主,占总用药的86.43%；药味以甘、苦、辛、淡为主,累计频率达86.67%；药性以寒、平、温为主,累计频率达93.08%；归经以肝、膀胱、脾、胃、肾、肺、心为主,累计频率达83.67%。结论 临床以利水渗湿药、补虚药、活血化瘀药、理气药、清热药等中药运用较多,核心单味药依次为金钱草、甘草、滑石、海金沙、车前子、石韦、川牛膝、冬葵子、鸡内金、木通等。
关键词：数据挖掘；尿道结石；用药规律；文献研究
DOI：10.3969/j.issn.1005-5304.2013.08.010
中图分类号：R2-05；R277.55
文献标识码：A
文章编号：1005-5304(2013)08-0026-03Medication Rule of TCM Treatment for Urinary Lithiasis Based on Literature LIU Xin-fa1, LI Ting-bao2 (1.The Third People"s Hospital of Lanzhou City, Lanzhou 730050, China；2.Gansu College of TCM, Lanzhou 730000, China)
Abstract：Objective To study the medication rule of traditional Chinese medicine treatment of urinary stone disease data mining. Methods Clinical study literature in China Journal Full-text Database 1985－2012 on Chinese medicine prescription of urinary stone disease were retrieved, database was established and analyzed by SPSS12.0 statistical software. Results There were 209 literatures meeting the inclusion criteria of Chinese medicine for urinary lithiasis, including 209 oral administration compound, 234 kinds of traditional Chinese medicine, 1843 times of frequency. The traditional Chinese medicine mainly for diuresis and diffusing dampness, restoring vital energy, blood-activating and removing stasis, regulating qi, clearing heat, promoting digestion and purgation, counted for 86.43%；with flavour of sweet, bitter, spicy, fresh, counted for 86.67%；nature of cold, plain, warm, counted for 93.08%；meridian tropism of liver, bladder, spleen, stomach, kidney, lung, heart, counted for 83.67%. Conclusion Trditional Chinese medicine of diuresis and diffusing dampness, restoring vital energy, blood-activating and removing stasis, regulating qi, clearing heat were commonly used. The core single medicine are Lysimachiae Herba, Glycyrrhizae Radix, Talcum, Lygodii Spora, Plantaginis Semen, Pyrrosiae Folium, Cyathulae Radix, Malvae Fructus, Galli Gigerii Endothelium Corneum, Akebiae caulis, etc.
Key words：data mining；urinary lithiasis；medicine rule；literature research基金项目：国家中医药管理局-全国名老中医王文春学术思想研究工作室项目(2010年)通讯作者：李廷保,E-mail：LTB813@126.com
尿道结石是一种尿路结石引发的泌尿系统疾病,西医对其病因病机进行了较深入的研究,在治疗方面也有取得一定的进展[1]。中医治疗本病有一定的特色优势,值得深入研究。本研究通过文献整理,运用统计学方法分析其处方用药规律,[25] 魏旭兰,王亦民,袁飞锋.维生素E抗肿瘤作用机制研究[J].现代诊断与治疗,2010,21(3)：189-191. [26] 钱霞,李菁,丁建花,等.格列苯脲通过激活ROS-JNK通路发挥抗肿瘤作用[C]//中国药理学会生化与分子药理学专业委员会.全国生化与分子药理学药物靶点研讨会论文摘要集.郑州：中国药理学会生化与分子药理学专业委员会,2008.[27] 张浩,唐军.血红蛋白抗肿瘤作用的实验研究进展[J].国外医学：肿瘤学分册,1999,26(4)：11-13. [28] MA Bing, XIANG Yang, LI Tao, et al. Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water chanel[J]. Acta Pharmacol Sin, 2004,25(1)：54-60.[29] 吴乾.复方氨基酸胶囊在恶性肿瘤化疗中的临床应用[J].中国药物与临床,2010,10(8)：951-952.[30] 姚旌,王林,陆魏.多塞平对骨癌疼痛模型大鼠的镇痛作用研究[J].中国药房,2012,23(1)：31-33.
